Imipramine Poisoning in Childhood

Treatment of severe imipramine poisoning.

The clinical effects and treatment of imipramine and amitriptyline poisoning have been reviewed by Giles (1963) and Steel, O'Duffy, and Brown (1967). The majority of cases are mild and recover spontaneously. The severe case is characterized by coma, convulsions, and cardiac arrhythmias. There is the added risk of respiratory depression and hypotension. Poisoning is severe if the dose of the dru...

Amitriptyline and imipramine poisoning in children.

The increasing number of children admitted to this hospital with poisoning by tricyclic antidepressants is causing concern. Of 60 children admitted between January 1966 and July 1973, half were admitted in the last 18 months. In 60% of these patients the tricyclic compounds had been prescribed for nocturnal enuresis. One child aged 2 years and 4 months died of imipramine poisoning. It is impera...

Nonaccidental poisoning in childhood.

A boy aged 7 years 10 months was admitted to hospital on several occasions in an unconscius state with twitching and apnoeic episodes. Initial investigations failed to show a specific cause. During his time in hospital he had recurrent episodes of loss of consciousness and, on the last occasion, hypotension and ventricular tachycardia. A diagnosis of imipramine poisoning was established by the ...

Accidental poisoning in childhood.

A recent increase in the number of children brought to hospital with accidental poisoning has been noticed in Edinburgh and Aberdeen. In a study of this trend, which has also been recorded in Manchester (Holzel and James, 1951), we have tried to determine whether it reflects a true increase of poisoning in the child population. We have then compared the incidence of the individual toxic agents ...

Poisoning Accidents in Childhood.